Shivamallu, C. and Sharanaiah, U. and Kollur, S. P. and Mallesh, N. K. R. and Hosakere, R. D. and Balamurugan, V. (2014) Pseudo-peptides as novel antileptospiral agents: Synthesis and spectral characterization. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 118. pp. 1152-1157.
Full text not available from this repository. (Request a copy)Abstract
In this paper, we describe the synthesis of novel class of pseudo-peptides derived by coupling an amino acid with a heterocyclic moiety containing free amine group using suitable coupling agents. The synthesized compounds were characterized using spectral (1H NMR, 13C NMR and MS) techniques. Preliminary pharmacological assays for Leptospirosis were studied by test tube dilution (TDT) and micro dilution technique (MDT). In particular, all the analyses led to the conclusion that the synthesized compound inhibiting the Leptospira a causal organism of Leptospirosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | human, Spectroscopic technique, chemical structure, chemistry, Humans, synthesis, drug effect, Anti-Bacterial Agents, antiinfective agent, Nuclear magnetic resonance spectroscopy, article, minimum inhibitory concentration, Peptides, Leptospira, leptospirosis, Leptospirosis, Spectrum analyzers, Amino acids, Models, Molecular, Minimum inhibitory concentration, drug derivative, Tryptophan, tryptophan, Anti-leptospiral activity, Coupling agents, Dilution technique, Free amines, Heterocyclic moieties, peptidomimetic agent, Peptidomimetics, Pseudo-peptide, Spectral characterization, Test tube |
| Subjects: | B Life Science > Biotechnology C Chemical Science > Chemistry |
| Divisions: | Department of > Biotechnology Department of > Chemistry |
| Depositing User: | Arshiya Kousar Library Assistant |
| Date Deposited: | 14 Jul 2019 10:02 |
| Last Modified: | 14 Jul 2019 10:02 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/4430 |
Actions (login required)
 |
View Item |
