Roopashree, R. and Swaroop, T. R. and Jagadish, S. and Mohan, C. D. and Rangappa, K. S. (2014) Synthesis and cholinesterase inhibition activity of new pyrrolopyrimidine derivatives. Letters in Drug Design and Discovery, 11 (10). pp. 1143-1148.
Full text not available from this repository. (Request a copy)Abstract
Cholinesterase plays a vital role in the decline of cholinergic transmission and thus can contribute to the development of Alzheimer's disease (AD). Thus, compounds that can inhibit acetylcholinesterase (AChe) and butyrylcholinesterase (BuChe) are the potential drugs for the treatment of AD. A series of novel pyrrolopyrimidine derivatives was synthesized and evaluated for their inhibitory activity against cholinesterase by Ellman method. Among the ten newly synthesized compounds, 4-(4-((4-(difluoromethoxy)phenyl)amino)-7H-pyrrolo 2,3-dpyrimidin-6-yl)benzoate was the most potent molecule identified with the IC50 values of 18 μM and 17 uM on AChe and BuChe respectively.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Article, drug potency, drug synthesis, IC50, in vitro study, proton nuclear magnetic resonance, unclassified drug, priority journal, acetylcholinesterase, cholinesterase, cholinesterase inhibition, Alzheimer disease, blood sampling, 3 d]pyrimidin 6 yl]benzoate, 3 d]pyrimidin 6yl]benzoate, cholinergic transmission, ethyl 4 4 (3 chlorophenylamino) 7h pyrrolo2, ethyl 4 4 (3 fluorophenylamino) 7h pyrrolo2, ethyl 4 4 (3 methoxyphenylamino) 7h pyrrolo2, ethyl 4 4 (4 bromophenylamino) 7h pyrrolo2, ethyl 4 4 (4 fluorophenylamino) 7h pyrrolo2, ethyl 4 4 (4 methoxyphenylamino) 7h pyrrolo2, ethyl 4 4 (p tolylamino) 7h pyrrolo2, ethyl 4 4 (phenylamino) 7h pyrrolo2, optical density, pyrrolopyrimidine derivative |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Arshiya Kousar Library Assistant |
| Date Deposited: | 21 Aug 2019 07:13 |
| Last Modified: | 21 Aug 2019 07:13 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/4378 |
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