Prashanth, M. K. and Revanasiddappa, H. D. (2014) Synthesis and antioxidant activity of novel quinazolinones functionalized with urea/thiourea/thiazole derivatives as 5-lipoxygenase inhibitors. Letters in Drug Design and Discovery, 11 (6). pp. 712-720.
Full text not available from this repository. (Request a copy)Abstract
In the present study, a series of novel quinazolinones functionalized with urea/thiourea/thiazole derivatives was synthesized and evaluated for their antioxidant and 5-lipoxygenase (5-LOX) inhibition activities. The newly synthesized compounds were characterized using 1H NMR, 13C NMR, IR, Mass spectra and elemental analysis. The antioxidant activities of the title compounds were evaluated using DPPH, superoxide, hydroxyl and nitric oxide radical scavenging assay in vitro. It is revealed from the antioxidant screening results that the compounds 3e, 5f and 6c manifested profound antioxidant potential. The synthesized compounds were screened for their 5-LOX inhibitory activity. Overall, 3e, 5f and 6c showed promising antioxidant and 5f showed 5-LOX inhibitory activity and may be used as the lead compounds in the future study.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 3, carbon nuclear magnetic resonance, drug synthesis, in vitro study, infrared spectroscopy, mass spectrometry, proton nuclear magnetic resonance, structure activity relation, unclassified drug, drug screening, priority journal, antioxidant, antioxidant activity, enzyme activity, 1, nitric oxide, drug efficacy, article, 2, thin layer chromatography, superoxide, hydroxyl group, nuclear magnetic resonance, liquid chromatography, melting point, thiazole derivative, 1 diphenyl 2 picrylhydrazyl, IC 50, scavenger, thiourea derivative, urea derivative, lipoxygenase inhibitor, 1 methyl 2, 1 methyl 3 (4 phenylthiazol 2 yl)quinazoline 2, 1 methyl 3 4 (p tolyl)thiazol 2 ylquinazoline 2, 2 dihydroquinazoline 3 (4h) carboxamide, 2 dihydroquinazoline 3(4h) carbothiomide, 2 dihydroquinazoline 3(4h) carboxamide, 3 4 (4 chlorophenyl)thiazol 2 yl 1 methylquinazoline 2, 3 4 (4 methoxyphenyl)thiazol 2 yl 1 methylquinazoline 2, 3h) dione, 3h)dione, 4 chloro n (1 methyl 2, 4 dioxo 1, 4 dioxo n (p tolyl) 1, 4 fluoro n (1 methyl 2, 4 hydroxy n (1 methyl 2, 4 tetrahydroquinazoline 3 carbonothioyl)benzamide, 4 trifluoro n (1 methyl 2, 4(1h, 5 difluoro n (1 methyl 2, carbon 13, enzyme inhibition assay, hydroxyl radical scavenging assay, n (2 chlorophenyl) 1 methyl 2, n (3 chlorophenyl) 1 methyl 2, n (4 chlorophenyl) 1 methyl 2, n (4 fluorophenyl) 1 methyl 2, n (4 methoxyphenyl) 1 methyl 2, quinazolinone derivative |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Arshiya Kousar Library Assistant |
| Date Deposited: | 23 Aug 2019 06:59 |
| Last Modified: | 23 Aug 2019 06:59 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/4369 |
Actions (login required)
 |
View Item |
