Recyclable, graphite-catalyzed, four-component synthesis of functionalized pyrroles

Nandeesh, K. N. and Raghavendra, G. M. and Revanna, C. N. and Jenifer Vijay, T. A. and Rangappa, K. S. and Mantelingu, K. (2014) Recyclable, graphite-catalyzed, four-component synthesis of functionalized pyrroles. Synthetic Communications, 44 (8). pp. 1103-1110. ISSN 0039-7911

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Abstract

A facile, convenient, and multicomponent coupling strategy for the synthesis of highly functionalized pyrroles is developed using graphite as a catalyst, but devoid of moisture-sensitive metal catalysts and corrosive acidic reagents. This method involves four-component coupling reactions of ethyl acetoacetate compound or diethyl acetylene dicarboxylate, amines, aromatic aldehydes, and nitromethane without an inert atmosphere. This approach provides easy access to highly substituted pyrroles in good yields via one-pot tandem reaction. The method is very simple, straightforward, and environmentally friendly compared to the existing methods.

Item Type:	Article
Uncontrolled Keywords:	drug synthesis, unclassified drug, article, reaction time, catalyst, recycling, one pot synthesis, acidity, solvent effect, reagent, amine, solvent, moisture, aldehyde, 3 dicarboxylic acid, acetoacetic acid derivative, acetylene, alkene, aromatization, corrosion, dicarboxylic acid, diethyl 1 benzyl 4 (4 chlorophenyl) 1h pyrrole 2, enamine, graphite, Lewis acid, nitromethane, pyrrole derivative
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Arshiya Kousar Library Assistant
Date Deposited:	02 Jul 2019 11:22
Last Modified:	19 Dec 2020 05:59
URI:	http://eprints.uni-mysore.ac.in/id/eprint/3948

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