Nandeesh, K. N. and Swarup, H. A. and Sandhya, N. C. and Mohan, C. D. and Pavan Kumar, C. S. and Kumara, M. N. and Mantelingu, K. and Ananda, S. and Rangappa, K. S. (2016) Synthesis and antiproliferative efficiency of novel bis(imidazol-1-yl)vinyl-1,2,4-oxadiazoles. New Journal of Chemistry, 40 (3). pp. 2823-2828.
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Abstract
A new approach for the synthesis of novel bis(imidazol-1-yl)vinyl-1,2,4-oxadiazoles has been developed. This method operates in a single step giving the products in good to excellent yields. Antiproliferative efficiency of the synthesized compounds was tested against HCT116 (colon cancer) and A549 (lung cancer) cell lines. Among them, compounds 3m (IC50, 9.7 μM) and 3h (IC50, 20.3 μM) were found to be the best antiproliferative agents.
| Item Type: | Article |
|---|---|
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Manjula P Library Assistant |
| Date Deposited: | 26 Jun 2019 06:13 |
| Last Modified: | 19 Dec 2020 06:39 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/3868 |
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