Keerthi Kumar, S. and Paricharak, Shardul and Mohan, C. D. and Bharathkumar, H. and Nagabhushana, G. P. and Rajashekar, D. K. and Chandrappa, G. T. and Bender, A. and Basappa and Rangappa, K. S. (2016) Nano-MoO3-mediated synthesis of bioactive thiazolidin-4-ones acting as anti-bacterial agents and their mode-of-action analysis using in silico target prediction, docking and similarity searching. New Journal of Chemistry, 40 (3). pp. 2189-2199.
Full text not available from this repository. (Request a copy)Abstract
The efficacy of thiazolidin-4-ones as synthons for diverse biological small molecules has given impetus to anti-bacterial studies. Our work aims to synthesize novel bioactive thiazolidin-4-ones using nano-MoO3 for the first time. The compelling advantage of using nano-MoO3 is that the recovered nano-MoO3 can be reused thrice without considerable loss of its catalytic activity. The synthesized thiazolidin-4-ones were tested for anti-bacterial activity against two strains of pathogenic bacteria, namely, Salmonella typhi and Klebsiella pneumoniae. Our results indicated that 3-(benzodisoxazol-3-yl)-2-(3-methoxyphenyl)thiazolidine-4-one (compound 3b) showed significant inhibitory activity towards Salmonella typhi{,} in comparison with gentamicin. Furthermore{,} in silico target prediction presented the target of compound 3b as the FtsK motor domain of DNA translocase of Salmonella typhi. Hence{,} our hypothesis is that compound 3b may disrupt chromosomal segregation and thereby inhibit the division of Salmonella typhi. In addition{,} similarity searching showed that 34 compounds with a chemical similarity of 70% or higher to compound 3b{,} which were retrieved from ChEMBL{,} bound to targets associated with biological processes related to cell development in 36% of the cases. In summary{,} our work details novel usage of nano-MoO3 for the synthesis of novel thiazolidin-4-ones possessing anti-bacterial activity{,} and presents a mode-of-action hypothesis.
| Item Type: | Article |
|---|---|
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Manjula P Library Assistant |
| Date Deposited: | 26 Jun 2019 06:03 |
| Last Modified: | 01 Jul 2022 05:20 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/3866 |
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