Maniyazagan, M. and Mariadasse, R. and Jeyakanthan, J. and Lokanath, N. K. and Naveen, S. and Premkumar, K. and Muthuraja, P. and Manisankar, P. and Stalin, T. (2017) Rhodamine based “turn–on” molecular switch FRET–sensor for cadmium and sulfide ions and live cell imaging study. Sensors and Actuators B: Chemical, 238. 565 - 577. ISSN 0925-4005
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A novel fluorescent chemosensor based on a rhodamine derivative (RBD4) was designed, synthesized, and used as a selective Cd2+ ion sensor. The structure of the fluorescence sensor (RBD4) is confirmed through single crystal X-ray study. On the basis of the Förster resonance energy transfer mechanism between rhodamine and pyridine conjugated dyad, a new colorimetric as well as fluorescence probe was synthesized for the selective detection of Cd2+. This sensor shows high selectivity towards Cd2+ ions in the presence of other competing metal ions. On the basis of thorough experimental and theoretical findings, the additions of Cd2+ ions to the solution of RBD4 helps to generate a new fluorescence peak at 590nm due to the selective binding of Cd2+ ions with RBD4 in a 1: 1 ratio with a binding constant (K) of 4.2524×104M−1. The detection limit of RBD4 for Cd2+ was 1.025×10−8M, which presented a pronounced sensitivity towards Cd2+. The in situ generated RBD4–Cd2+ complex is able to selectively sense S2− over other anions based on the displacement approach, given a remarkable recovery of fluorescence and UV–vis absorption spectra. The fluorescence sensor has also exhibited very good results in HeLa Cells imaging under physiological pH.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Rhodamine, Fluorescence sensor, Förster resonance energy transfer, Metal ions, HeLa cells |
| Subjects: | D Physical Science > Physics |
| Divisions: | Department of > Physics |
| Depositing User: | C Swapna Library Assistant |
| Date Deposited: | 26 Jun 2019 05:12 |
| Last Modified: | 26 Jun 2019 05:12 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/3846 |
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