Madaiah, M. and Prashanth, M. K. and Revanasiddappa, H. D. and Veeresh, B. (2016) Synthesis and evaluation of novel imidazo[4,5-c]pyridine derivatives as antimycobacterial agents against Mycobacterium tuberculosis. New Journal of Chemistry, 40 (11). pp. 9194-9204.
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Abstract
The current study involves the synthesis of novel imidazo4{,}5-cpyridine derivatives (IPD) containing amide/urea/sulfonamide. The synthesized compounds were evaluated for in vitro and in vivo antimycobacterial activities against Mycobacterium tuberculosis. The pharmacological activities were determined by the objective to better understand their structure–activity relationship (SAR) for their in vitro antimycobacterial activity against M. tuberculosis. Some synthesized compounds showed significant activity against M. tuberculosis based on the agar dilution method. Among the forty-one compounds screened{,} compounds 21{,} 22 and 23 were found to be the most active compounds against M. tuberculosis. In the in vivo animal model{,} 21{,} 22 and 23 decreased the bacterial load in lung and spleen tissues at the dose of 50 mg kg−1 body weight.
| Item Type: | Article |
|---|---|
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Manjula P Library Assistant |
| Date Deposited: | 25 Jun 2019 09:40 |
| Last Modified: | 11 Dec 2019 09:27 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/3817 |
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