Synthesis, characterization, and evaluation of difluoropyrido4,3-bindoles as potential agents for Acetylcholinesterase and Antiamnesic activity

Madaiah, M. and Jayanna, B. K. and Manu, A. S. and Prashanth, M. K. and Revanasiddappa, H. D. and Veeresh, B. (2017) Synthesis, characterization, and evaluation of difluoropyrido4,3-bindoles as potential agents for Acetylcholinesterase and Antiamnesic activity. Archiv der Pharmazie, 350 (3-4). ISSN 1521-4184

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Abstract

Acetylcholinesterase (AChE) inhibitors are currently the most widely prescribed drugs for Alzheimer's disease. The high potential of indole compounds in medicinal chemistry led us to discover a novel series of fluoroindole compounds. The synthesis and pharmacological analysis of the difluoropyrido4,3-bindoles 11–34 are described. Compounds 11–34 were tested for AChE inhibition activity using a rat brain homogenate. Compounds 25–29 display a promising in vitro profile with an IC50 value range of 46–51.6 nM and show significant protective effect on scopolamine-induced amnesia. The present data indicate that compounds 25–29 may represent attractive potent molecules for the treatment of Alzheimer's disease.

Item Type:	Article
Uncontrolled Keywords:	Acetylcholinesterase, Alzheimer's disease, Antiamnesic activity, Difluoropyrido4,3-bindoles
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	C Swapna Library Assistant
Date Deposited:	25 Jun 2019 04:57
Last Modified:	01 Jul 2019 05:49
URI:	http://eprints.uni-mysore.ac.in/id/eprint/3779

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