Kamat, Vinayak and Kokare, Dhoolesh and Naik, Krishna and Kotian, Avinash and Naveen, S. and Dixit, Sheshagiri R. and Lokanath, N. K. and Joshi, Shrinivas D. and Revankar, Vidyanand K. (2017) Transition metal complexes of 2-(2-(1H-benzodimidazol-2-yl)hydrazono)propan-1-ol: Synthesis, characterization, crystal structures and anti-tuberculosis assay with docking studies. Polyhedron, 127. 225 - 237. ISSN 0277-5387
Full text not available from this repository. (Request a copy)Abstract
Transition metal coordination complexes of Co(II), Ni(II), Cu(II) and Zn(II) with a newly designed ligand, 2-(2-(1H-benzodimidazol-2-yl)hydrazono)propan-1-ol have been synthesized and characterized using various spectro-analytical techniques. The molecular structures of Co(II), Cu(II) and Zn(II) complexes are determined by single-crystal X-ray diffraction method. The metal to ligand stoichiometry has been found to be 1:2 in the case of Cobalt(II), Nickel(II) and Zinc(II) whereas 1:1 in the case of Copper(II) complex. The newly synthesized ligand and complexes have been assessed for their growth inhibiting potencies against H37Rv strain of Mycobacterium tuberculosis. The copper and cobalt complexes have emerged to be potent in vitro growth inhibitors of H37Rv. All the complexes are inhibiting the growth of other tested common microbial flora to a significantly lesser extent, making them selective towards H37Rv in the preliminary analysis. The consensus scores obtained by the docking studies of the molecules to the target protein enoyl acyl carrier protein reductase of M. tuberculosis H37Rv are in good agreement with the obtained MIC values.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | 2-(2-(1H-benzodimidazol-2-yl)hydrazono)propan-1-ol, 2-Hydrazinobenzimidazole, Transition metal complexes, Antituberculosis against H37Rv, Enoyl acyl carrier protein reductase of H37Rv |
| Subjects: | D Physical Science > Physics |
| Divisions: | Department of > Institution of Excellence |
| Depositing User: | C Swapna Library Assistant |
| Date Deposited: | 24 Jun 2019 09:54 |
| Last Modified: | 24 Jun 2019 09:54 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/3659 |
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