A new general method for the synthesis of thiophenes through acid mediated cyclization of mixed acetals derived from β-oxodithiates and bromoacetaldehyde acetal

Pradeepa Kumara, C. S. and Byre Gowda, G. and Ramesh, N. and Sadashiva, M. P. and Junjappa, H. (2016) A new general method for the synthesis of thiophenes through acid mediated cyclization of mixed acetals derived from β-oxodithiates and bromoacetaldehyde acetal. Tetrahedron Letters, 57 (23). 2520 - 2523.

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Official URL: https://doi.org/10.1016/j.tetlet.2016.04.100

Abstract

β-oxodithioates react with bromoacetaldehyde diethylacetal in the presence of anhydrous potassium carbonate in dimethyl formamide at 80°C to yield the corresponding mixed acetals. These acetals undergo smooth cyclization in the presence of ethanolic orthophosphoric acid to afford the corresponding 2-methylthio-3-acyl/aroyl/heteroaroyl thiophenes in 64–85 high overall yields.

Item Type: Article
Uncontrolled Keywords: β-Oxodithioates, α-Oxoketene dithioacetals, Bromoacetaldehyde diethylacetal
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Manjula P Library Assistant
Date Deposited: 21 Jun 2019 05:25
Last Modified: 21 Jun 2019 05:25
URI: http://eprints.uni-mysore.ac.in/id/eprint/3572

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