Synthesis and anticonvulsant activity of N-(substituted)-1-methyl-2,4-dioxo-1,2-dihydroquinazoline-3(4H)-carboxamides

Deepakumari, H. N. and Jayanna, B. K. and Prashanth, M. K. and Revanasiddappa, H. D. and Veeresh, B. (2016) Synthesis and anticonvulsant activity of N-(substituted)-1-methyl-2,4-dioxo-1,2-dihydroquinazoline-3(4H)-carboxamides. Aarchiv der Pharmazie, 349 (7). pp. 566-571.

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Abstract

A series of new N‐(substituted)‐1‐methyl‐2,4‐dioxo‐1,2‐dihydroquinazoline‐3(4H)‐carboxamides were designed, synthesized, and evaluated for their anticonvulsant activity. Most of the synthesized compounds exhibited potent anticonvulsant activities in the maximal electroshock (MES) and pentylenetetrazol (PTZ) test. The most promising compound 4c showed significant anticonvulsant activity with a protective index value of 3.58. The compounds 4a–c were also found to have encouraging anticonvulsant activity in the MES and PTZ screen when compared with the standard drugs, valproate and methaqualone. The same compounds were found to exhibit advanced anticonvulsant activity as well as lower neurotoxicity than the reference drug

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Manjula P Library Assistant
Date Deposited:	20 Jun 2019 07:41
Last Modified:	18 Sep 2019 11:22
URI:	http://eprints.uni-mysore.ac.in/id/eprint/3482

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