Arunseshan, C. and Giorgia Novajra and Irene Carmagnola and Piergiorgio Gentile and Sonia Fiorilli and Marta Miola and Manjunatha, B. and Arivuoli, D. and Gianluca Ciardelli and Chiara Vitale-Brovarone (2016) Physico-chemical and biological studies on three-dimensional porous silk/spray-dried mesoporous bioactive glass scaffolds. Ceramics International, 42 (12). 13761 - 13772.
Full text not available from this repository. (Request a copy)Abstract
The incorporation of a bioactive inorganic phase in polymeric scaffolds is a good strategy for the improvement of the bioactivity and the mechanical properties, which represent crucial features in the field of bone tissue engineering. In this study, spray-dried mesoporous bioactive glass particles (SD-MBG), belonging to the binary system of SiO2-CaO (80:20mol), were used to prepare composite scaffolds by freeze-drying technique, using a silk fibroin matrix. The physico-chemical and biological properties of the scaffolds were extensively studied. The scaffolds showed a highly interconnected porosity with a mean pore size in the range of 150µm for both pure silk and silk/SD-MBG scaffolds. The elastic moduli of the silk and silk/SD-MBG scaffolds were 1.1±0.2MPa and 6.9±1.0MPa and compressive strength were 0.5±0.05MPa and 0.9±0.2MPa, respectively, showing a noticeable increase of the mechanical properties of the composite scaffolds compared to the silk ones. The contact angle value decreased from 105.3° to 71.2° with the incorporation of SD-MBG particles. Moreover, the SD-MBG incorporation countered the lack of bioactivity of the silk scaffolds inducing the precipitation of hydroxyapatite layer on their surface already after 1 day of incubation in simulated body fluid. The composite scaffolds showed good biocompatibility and a good alkaline phosphatase activity toward human mesenchymal stromal cells, showing the ability for their use as three-dimensional constructs for bone tissue engineering.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Silk fibroin, Mesoporous bioactive glass, Composite scaffolds, Bone tissue engineering |
| Subjects: | B Life Science > Sericulture |
| Divisions: | Department of > Sericulture Science |
| Depositing User: | Manjula P Library Assistant |
| Date Deposited: | 20 Jun 2019 06:27 |
| Last Modified: | 16 Jul 2022 06:01 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/3427 |
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