Madhuri, K. and Naik, Prakash Ramachandra (2017) Modulatory effect of garcinol in streptozotocin-induced diabetic Wistar rats. Archives of Physiology and Biochemistry, 123 (5). pp. 322-329.
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AbstractThe objective of the study was to evaluate the efficacy of garcinol as an antidiabetic candidate in streptozotocin-induced diabetic Wistar rats. Diabetic rats showed a significant increase in the biochemical parameters such as fasting blood glucose, glycated haemoglobin, urea, alanine aminotransferase and aspartate aminotransferase, malondialdehyde, total cholesterol, triglycerides, low-density lipoprotein cholesterol, very low-density lipoprotein cholesterol, atherogenic index and a significant decrease in plasma insulin, HOMA-β-cell functioning index, glycogen, high-density lipoprotein cholesterol, body weight and antioxidant enzyme activities, viz. superoxide dismutase, catalase and reduced glutathione. Oral administration of garcinol (10 and 20 mg/kg body weight/day) for 30 days improved the above-mentioned alterations. The effect produced by the drug was compared with that of glibenclamide, a standard hypoglycaemic drug. These findings reveal that garcinol can be a promising antidiabetic candidate in the future.
| Item Type: | Article |
|---|---|
| Additional Information: | PMID: 28598692 |
| Uncontrolled Keywords: | Antidiabetic;Antihyperlipidaemic;Antioxidant;Oxidative Stress; Glibenclamide |
| Subjects: | B Life Science > Sericulture |
| Divisions: | Department of > Zoology |
| Depositing User: | C Swapna Library Assistant |
| Date Deposited: | 19 Jun 2019 05:39 |
| Last Modified: | 19 Jun 2019 05:39 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/3389 |
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