Synthesis, characterization, biological and catalytic applications of transition metal complexes derived from Schiff base

Bushra Begum, A. and Rekha, N. D. and Vasantha Kumar, B. C. and Lakshmi Ranganatha, V. and Khanum, S. A. (2014) Synthesis, characterization, biological and catalytic applications of transition metal complexes derived from Schiff base. Bioorganic and Medicinal Chemistry Letters, 24 (15). pp. 3559-3564. ISSN 0960-894X

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Abstract

A novel series of Cu(II), Ni(II), Zn(II), Co(II), and Cd(II) complexes have been synthesized from the Schiff base. Structural features were determined by analytical and spectral techniques like IR, 1H NMR, UV-vis, elemental analysis, molar electric conductibility, magnetic susceptibility and thermal studies. The complexes are found to be soluble in dimethylformamide and dimethylsulfoxide. Molar conductance values in dimethylformamide indicate the non-electrolytic nature of the complexes. Binding of synthesized complexes with calf thymus DNA (CT DNA) was studied. There is significant binding of DNA in lanes 2, 3, and 5. Lanes 4 and 6 are showing more florescence when compared to the control indicating that these molecules are strongly bound to the DNA by inserting themselves between the two stacked base pairs and exhibiting their original property of fluorescence. Angiogenesis study has revealed that the compounds B-2, B-4 and B-5 have potent antitumor efficacy and activation of antiangiogenesis could be one of the possible underlying mechanisms of tumor inhibition.

Item Type:	Article
Uncontrolled Keywords:	antiangiogenic activity, antineoplastic activity, antineoplastic agent, Article, controlled study, drug synthesis, mass spectrometry, nonhuman, proton nuclear magnetic resonance, structure activity relation, unclassified drug, animal, Animals, Antineoplastic Agents, Antitumor, chemical structure, chemistry, drug screening, Drug Screening Assays, drug structure, Molecular Structure, Structure-Activity Relationship, synthesis, dose response, Dose-Response Relationship, Drug, pathology, DNA, 1, drug efficacy, cell proliferation, copper, copper complex, DNA binding, thermogravimetry, article, Cell Proliferation, catalysis, Catalysis, ultraviolet spectroscopy, angiogenesis, elemental analysis, Neovascularization, gel electrophoresis, Neoplasms, bovine, calf thymus DNA, Cattle, thymus, catalyst, drug effects, cadmium, nickel, zinc, Fluorescence, carbonyl derivative, thermostability, Pathologic, Schiff base, Angiogenesis Inhibitors, infrared radiation, dimethyl sulfoxide, magnetism, Bovinae, analytic method, conductance, n, angiogenesis inhibitor, Schiff Bases, fluorescence, 2 phenylenediamine, cadmium complex, cadmium derivative, calf thymus dna, cobalt, cobalt complex, DNA fragmentation assay, electric field, metal complex, molar electric conductibility, n dimethylformamide, nickel complex, organometallic compound, Organometallic Compounds, transition element, Transition Elements, zinc complex
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry Yuvaraj college > Chemistry
Depositing User:	Arshiya Kousar Library Assistant
Date Deposited:	18 Jun 2019 05:14
Last Modified:	18 Jun 2019 05:14
URI:	http://eprints.uni-mysore.ac.in/id/eprint/3170

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