Joseph, Jayan T. and Sajith, Ayyiliath M. and Ningegowda, R. C. and Sheena, S. (2017) Room temperature carbonylation of (Hetero) aryl pentafluorobenzenesulfonates and triflates using palladium-cobalt bimetallic catalyst: dual role of cobalt carbonyl. Advanced Synthesis & Catalysis, 359 (3). pp. 419-425. ISSN 1615-4169
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Abstract An efficient method for the carbonylation of (hetero) aryl pentafluorobenzenesulfonates and triflates under exceptionally mild conditions using palladium/dicobalt octacarbonyl Pd/Co2(CO)8 has been developed. Besides acting as carbon monoxide (CO) source, Co2(CO)8 enhances the reaction rate by accelerating the CO insertion through an in situ generated bimetallic palladium cobalt tetracarbonyl Pd-Co(CO)4 complex. Under the optimized reaction condition, carbonylation of a wide range of activated and deactivated, as well as sterically hindered and heteroaromatic, substrates proceeded efficiently at room temperature. The high chemoselectivity and improved synthesis of biologically relevant Isoguvacine and Lazabemide intermediates highlights its scope as a valuable synthetic method. The generality of this protocol was further extended to other electrophiles (bromides, chlorides and tosylates).
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | bimetallic catalysis, carbonylation, chemoselectivity, cobalt, palladium |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | C Swapna Library Assistant |
| Date Deposited: | 14 Jun 2019 09:33 |
| Last Modified: | 28 Jun 2019 09:54 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/3092 |
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