Mahentesha, B. and Jambagi, V. B. and Barigidad, N. N. and Laxmeshwar, S. S. and Devaru, V. and Narayanachar (2014) Synthesis, structure-activity relationship of iodinated-4-aryloxymethyl- coumarins as potential anti-cancer and anti-mycobacterial agents. European Journal of Medicinal Chemistry, 74. pp. 225-233. ISSN 0223-5234
Full text not available from this repository. (Request a copy)Abstract
A series of new iodinated-4-aryloxymethylcoumarins 6, 8 and 10 have been obtained from the reaction of various 4-bromomethylcoumarins 4 with 2-iodophenol 5, 3-iodophenol 7 and 4-iodophenol 9 respectively. All the title compounds were screened for anticancer activity against two cancer cell lines (MDA-MB human adenocarcinoma mammary gland and A-549 human lung carcinoma) and two mycobacterial strains (Mycobacterium tuberculosis H37 RV and Mycobacterium phlei). The SAR results indicate that nine compounds are potent, among these 10h and 10i having chlorine are most effective. This is the first report assigning in vitro anti-mycobacterial, anticancer and structure-activity relationship for this new class of iodinated-4-aryloxymethyl-coumarins. © 2014 Elsevier Masson SAS. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | antineoplastic activity, controlled study, drug potency, drug synthesis, human, human cell, in vitro study, structure activity relation, unclassified drug, Antineoplastic Agents, Cell Line, drug screening, Humans, Structure-Activity Relationship, Tumor, Coumarin, drug efficacy, article, human cell culture, unindexed drug, Microbial Sensitivity Tests, streptomycin, Antitubercular Agents, Mycobacterium tuberculosis, Coumarins, drug activity, coumarin derivative, Iodine, pyrazinamide, Anticancer, Heterocycles, SAR, lung carcinoma, cancer cell culture, breast adenocarcinoma, 1 (3 iodo phenoxymethyl)benzofchromen 3 one, 1 (4 iodo phenoxymethyl)benzofchromen 3 one, 4 (2 iodo phenoxymethyl) 6 methoxy chromen 2 one, 4 (2 iodo phenoxymethyl) 7 methoxy chromen 2 one, 4 (2 iodo phenoxymethyl)benzofchromen 3 one, 4 (2 iodo phenoxymethyl)benzohchromen 2 one, 4 (3 iodo phenoxymethyl) 6 methoxy chromen 2 one, 4 (3 iodo phenoxymethyl) 6 methyl chromen 2 one, 4 (3 iodo phenoxymethyl) 7, 4 (3 iodo phenoxymethyl) 7 methoxy chromen 2 one, 4 (3 iodo phenoxymethyl) 7 methyl chromen 2 one, 4 (3 iodo phenoxymethyl)benzofchromen 2 one, 4 (4 iodo phenoxymethyl) 6 methoxy chromen 2 one, 4 (4 iodo phenoxymethyl) 6 methyl chromen 2 one, 4 (4 iodo phenoxymethyl) 7, 4 (4 iodo phenoxymethyl) 7 methoxy chromen 2 one, 4 (4 iodo phenoxymethyl) 7 methyl chromen 2 one, 4 (4 iodo phenoxymethyl)benzohchromen 2 one, 6 bromo 4 (2 iodo phenoxymethyl)chromen 2 one, 6 bromo 4 (3 iodo phenoxymethyl)chromen 2 one, 6 chloro 4 (2 iodo phenoxymethyl)chromen 2 one, 6 chloro 4 (3 iodo phenoxymethyl)chromen 2 one, 6 chloro 4 (4 iodo phenoxymethyl)chromen 2 one, 7 chloro 4 (2 iodo phenoxymethyl)chromen 2 one, 7 chloro 4 (3 iodo phenoxymethyl)chromen 2 one, 7 chloro 4 (4 iodo phenoxymethyl)chromen 2 one, 8 dimethyl chromen 2 one, Anti-mycobacterial, antitubercular activity, Mycobacterium phlei |
| Subjects: | M Polymer Science > Polymer Science |
| Divisions: | PG Centre Mandya > Polymer Science |
| Depositing User: | Arshiya Kousar Library Assistant |
| Date Deposited: | 15 Jun 2019 10:25 |
| Last Modified: | 20 Jun 2022 09:41 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/3059 |
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