Synthesis, characterization, and antibacterialactivity of 6-Chloro-8-methyl-2-oxo-2H-chromene-3-carboxylic acid ethyl ester

Latha Rani, N. and Prashanth, T. and Sridhar, M. A. and Gurupadaswamy, H. D. and Shaukath Ara Khanum and Lokanath, N. K. (2016) Synthesis, characterization, and antibacterialactivity of 6-Chloro-8-methyl-2-oxo-2H-chromene-3-carboxylic acid ethyl ester. Molecular Crystals and Liquid Crystals, 624 (1). pp. 262-270. ISSN 1563-5287

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Abstract

The title compound was synthesized by reacting 2-hydroxy-4-methoxy-benzaldehyde with diethyl malonate in the presence of piperidine cat-alyst and ethanol as solvent. The chemical structure of the title com-pound was elucidated by elemental analysis,1H-NMR, and IR. The crys-tal structure was determined by X-ray diffraction data. It crystallizes inmonoclinic crystal system, P21/c space group with unit cell parameters,a=12.840(2) ̊A, b=24.790(4) ̊A, c=7.8544(13) ̊A,β=98.035(5)°,V=2475.5(7) ̊A3,andZ=8. The molecular and crystal structure of the titlecompound is stabilized by inter- and intramolecular interactions of thetype C—H···O. The newly synthesized compound was screened for itsantibacterial activity against two gram-positive and two gram-negativebacteria.

Item Type:	Article
Subjects:	D Physical Science > Physics
Divisions:	Department of > Physics
Depositing User:	Manjula P Library Assistant
Date Deposited:	13 Jun 2019 11:20
Last Modified:	01 Dec 2022 05:49
URI:	http://eprints.uni-mysore.ac.in/id/eprint/3022

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