Naik, K. H. K. and Ashok, B. and Naik, N. and Mulla, J. A. S. and Prakasha, A. (2015) DNA binding, anti-inflammatory and analgesic evaluation of metal complexes of N/S/O donor ligands; Synthesis, spectral characterization. SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 141. pp. 88-93. ISSN 1386-1425
Full text not available from this repository. (Request a copy)Abstract
Transition metal complexes containing tri-dentate NSN donor ligands i.e., 5-((1(aminomethyl)cyclohexyl)methyl)-1,3,4-thiadiazol-2-amine (AMTA) (2) and 5-(2-aminophenyl)-1,3,4-thiadiazol-2-amine (ATA) (4i-ii) have been synthesized. The newly synthesized ligands and their respective complexes were characterized by elemental analysis, molar conductance measurement and various spectral studies infrared (IR), electronic, and NMR (for ligands only)]. Metal complexes are like M(AMTA)(2)], M(ATA)(2)] type, where M = Mn(II), Co(II) and Cu(II). The proposed geometries of the complexes are octahedral in nature. The synthesized ligands and their complexes were exhibits effective anti-inflammatory, analgesic and DNA binding activities. All the tested compounds exhibited significant analgesic activity, whereas the compound 4i, 4(ia) and 4(iib) is equipotent with Diclofenac sodium. (C) 2014 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Subjects: | B Life Science > Biotechnology C Chemical Science > Chemistry |
| Divisions: | Department of > Biotechnology Department of > Chemistry |
| Depositing User: | Users 19 not found. |
| Date Deposited: | 11 Jun 2019 09:24 |
| Last Modified: | 11 Jun 2019 09:24 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/2743 |
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