A concise synthetic strategy to functionalized chromenones via 5+1] heteroannulation and facile C-N/C-S/C-O bond formation with various nucleophiles

Savant, M. Mahesh and Neetha S. Gowda and Pansuriya, Akshay M. and Bhuva, Chirag V. and Kapuriya, N. and Anandalwar, Sridhar M. and Shashidhara Prasad, J. and Shah, Anamik and Yogesh, N. T. (2011) A concise synthetic strategy to functionalized chromenones via 5+1] heteroannulation and facile C-N/C-S/C-O bond formation with various nucleophiles. Tetrahedron Letters, 52 (2). pp. 254-257.

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Abstract

A highly efficient strategy to 2,3-substituted chromen-4H-ones has been developed. The methodology involves unexpected intramolecular heteroannulation of readily accessible substituted 2-hydroxy-omega-nitroacetophenone with carbon disulfide in the presence K(2)CO(3) followed by methylation with methyl iodide. These chromenones were further reacted with various nucleophiles such as amines, thiols, and alkoxide resulting in the facile C-N, C-S, and C-O bond formation. The scope and generality have been discussed. (C) 2010 Elsevier Ltd. All rights reserved.

Item Type: Article
Subjects: C Chemical Science > Chemistry
Depositing User: Users 23 not found.
Date Deposited: 14 Jun 2019 06:26
Last Modified: 07 Jul 2022 10:24
URI: http://eprints.uni-mysore.ac.in/id/eprint/2586

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