Sarojini, B. K. and Raj, C. G. and Ramakrishna, M. K. and Ramesh, S. R. and Bharath, B. R. and Manjunatha, H. (2011) In silico studies of (2E,5E)-2,5-bis(3-methoxy-4-hydroxy-benzylidene) cyclopentanone on proteins AChE and BChE involved in alzheimer's disease and ameliorative effects on paraquat induced oxidative stress markers in drosophila melanogaster. Letters in Drug Design & Discovery, 8 (3). pp. 260-267.
Full text not available from this repository. (Request a copy)Abstract
In the present study, the ameliorative effect of a bischalcone (2E,5E)-2,5-bis(3-methoxy-4-hydroxy-benzylidene) cyclopentanone (CA), a curcumin analog was studied on Drosophila melanogaster (oregon K strain) in vivo by inducing oxidative stress using paraquat. Curcumin (CU) was taken as standard for studies. In negative geotaxis assay it was found that CA was able to rescue the flies significantly from deteriorating locomotor dysfunctions. A docking study for antialzeimer's activity of CA was carried out by targeting the proteins Acetylcholinesterase (AChE) and Butyrylcholinesterase (BChE). It binds effectively to the target proteins.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Antioxidant; Alzheimer disease; Bischalcone; Paraquat; Molecular docking; Oxidative stress |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Users 23 not found. |
| Date Deposited: | 21 Jun 2019 09:53 |
| Last Modified: | 11 Oct 2019 05:52 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/2549 |
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