Urea/thiourea derivatives of quinazolinone-lysine conjugates: Synthesis and structure-activity relationships of a new series of antimicrobials

Suresha, G. P. and Suhas, R. and Kapfo, W. and Chenne Gowda, D. (2011) Urea/thiourea derivatives of quinazolinone-lysine conjugates: Synthesis and structure-activity relationships of a new series of antimicrobials. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 46 (6). pp. 2530-2540. ISSN 0223-5234

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Abstract

Synthesis of a series of urea/thiourea/acetamide/sulphonamide derivatives of quinazolinones conjugated lysine has been reported. Structures of the products have been determined by standard spectroscopical studies. All the compounds have been screened for their antibacterial studies and structure activity relationship has been developed. The activity profile revealed that the compounds containing urea and thiourea functionalities along with fluoro group have exerted a highly potent activity. Thus, the title compounds represent a novel class of potent antimicrobial agents. (C) 2011 Elsevier Masson SAS. All rights reserved.

Item Type:	Article
Uncontrolled Keywords:	Quinazolinone-lysine conjugates; Urea; Thiourea; Potent microbe inhibitors
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Users 23 not found.
Date Deposited:	08 Jul 2019 11:43
Last Modified:	06 Jul 2022 07:09
URI:	http://eprints.uni-mysore.ac.in/id/eprint/2484

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