Synthesis and evaluation of antioxidant and antibacterial activities of new substituted bis(1,3,4-oxadiazoles), 3,5-bis(substituted) pyrazoles and isoxazoles

Musad, E. A. and Mohamed, R. and Saeed, Bahjat Ali and Vishwanath, B. S. and Rai, K. M. Lokanatha (2011) Synthesis and evaluation of antioxidant and antibacterial activities of new substituted bis(1,3,4-oxadiazoles), 3,5-bis(substituted) pyrazoles and isoxazoles. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21 (12). pp. 3536-3540. ISSN 0960-894X

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Abstract

Two series of five membered heterocyclic bis(1,3,4-oxadiazole) derivatives 2(a-h) and 3,5-bis(substituted) pyrazoles, isoxazoles 3(a, b, d-i), 4(a-c) were synthesized via oxidative cyclization of some diaroylhydrazones using chloramine-T and cyclocondensation reaction with hydrazine hydrate and hydroxylamine hydrochloride, respectively. The newly synthesized compounds were screened for antioxidant and anti-microbial activities. Compounds 2(b), 3(b), and 4(a) showed higher antioxidant activity at 10 mu g/ml while compounds 2(a), 3(a), 3(f), and 4(a) exhibited better anti-microbial activity at 100 mu g/ml compared with standard vitamin C and ciprofloxacin, respectively. Structures of newly synthesized compounds were confirmed by elemental analysis and spectral IR, (1)H NMR, and (13)C NMR data. (C) 2011 Elsevier Ltd. All rights reserved.

Item Type:	Article
Uncontrolled Keywords:	Methylene-linked bis(1,3,4-oxadiazole) derivatives; 3,5-Bis(substituted) pyrazoles; Isoxazoles; Antioxidant; Antibacterial
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Users 23 not found.
Date Deposited:	15 Jul 2019 10:39
Last Modified:	13 Jan 2023 10:45
URI:	http://eprints.uni-mysore.ac.in/id/eprint/2471

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