Applications of gene editing and nanotechnology in stem cell-based therapies for human diseases

Bolideei, M. and Barzigar, R. and Gahrouei, R. B. and Mohebbi, E. and Haider, K. H. and Paul, S. and Paul, M. K. and Mehran, M. J. (2025) Applications of gene editing and nanotechnology in stem cell-based therapies for human diseases. Stem Cell Reviews and Reports, 21 (4). pp. 905-934. ISSN 2629-3269

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Official URL: https://doi.org/10.1007/s12015-025-10857-0

Abstract

Stem cell research is a dynamic and fast-advancing discipline with great promise for the treatment of diverse human disorders. The incorporation of gene editing technologies, including ZFNs, TALENs, and the CRISPR/Cas system, in conjunction with progress in nanotechnology, is fundamentally transforming stem cell therapy and research. These innovations not only provide a glimmer of optimism for patients and healthcare practitioners but also possess the capacity to radically reshape medical treatment paradigms. Gene editing and nanotechnology synergistically enhance stem cell-based therapies' precision, efficiency, and applicability, offering transformative potential for treating complex diseases and advancing regenerative medicine. Nevertheless, it is important to acknowledge that these technologies also give rise to ethical considerations and possible hazards, such as inadvertent genetic modifications and the development of genetically modified organisms, therefore creating a new age of designer infants. This review emphasizes the crucial significance of gene editing technologies and nanotechnology in the progress of stem cell treatments, particularly for degenerative pathologies and injuries. It emphasizes their capacity to restructure and comprehensively revolutionize medical treatment paradigms, providing fresh hope and optimism for patients and healthcare practitioners.

Item Type: Article
Uncontrolled Keywords: Stem cell therapy, Gene editing technologies, Nanoparticles, Nanotechnology, Regenerative medicine
Subjects: B Life Science > Biotechnology
Divisions: Department of > Biotechnology
Depositing User: Ms Varalakshmi
Date Deposited: 28 Oct 2025 05:56
Last Modified: 28 Oct 2025 06:16
URI: http://eprints.uni-mysore.ac.in/id/eprint/17871

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