Synthesis, characterization and antioxidant activity studies of new coumarin tethered 1,3,4-oxadiazole analogues

Vagish, C. and Sudeep, P. and Dileep Kumar, A. and Ajay Kumar, K. (2021) Synthesis, characterization and antioxidant activity studies of new coumarin tethered 1,3,4-oxadiazole analogues. Journal of Chemical Sciences, 133 (2). ISSN 0973-7103

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Abstract

The present work describes the synthesis of a series of substituted 3-(5-phenyl-1,3,4-oxadiazol-2-yl)-2H-chromen-2-ones 7(a-j) using substituted aldehydes with analogues of hydrazine hydrates by grinding technique in the presence of Iodine which helps in the cyclization process. The structures of the synthesized compounds were elucidated by spectroscopic techniques such as IR, H-1 NMR, C-13 NMR, and LCMS. The comparative antioxidant property (using DPPH and hydroxyl radical scavenging) has been studied with the synthesized compounds 7(a-j) and the standards. Compounds 7d and 7i show the prominent radical scavenging activity. Graphic abstract Synopsis: Series of ten new coumarin-oxadiazole hybrids synthesized in three steps starting from salicylaldehyde and diethylmalonate. All new compounds were spectroscopically characterized. The results of radical scavenging activities show that, two compounds of the series 7d and 7i displayed potent DPPH and hydroxyl radical activity comparable to the standards employed, and therefore acts as antioxidant leads.

Item Type:	Article
Uncontrolled Keywords:	Coumarin tethered 1,3,4-oxadiazoles; Aryl hydrazide; Fused heterocycle; Iodine; Grinding technique; Cyclization
Subjects:	C Chemical Science > Chemistry
Divisions:	Yuvaraj college > Chemistry
Depositing User:	C Swapna Library Assistant
Date Deposited:	13 Dec 2023 05:21
Last Modified:	13 Dec 2023 05:21
URI:	http://eprints.uni-mysore.ac.in/id/eprint/17778

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