Nagesh, Khadri M. J. and Prashanth, T. and Khamees, Hussien Ahmed and Shaukath Ara Khanum (2022) Synthesis, analgesic, anti-inflammatory, COX/5-LOX inhibition, ulcerogenic evaluation, and docking study of benzimidazole bearing indole and benzophenone analogs. Journal of Molecular Structure, 1259. ISSN 1872-8014
Full text not available from this repository. (Request a copy)Abstract
Inflammation therapy is particularly focused on the development of safer non-steroidal anti-inflammatory drugs (NSAIDs), administered to control inflammation. It is typically considered that dual-inhibition of COX/5-LOX, which improves efficacy and has fewer side effects, is an effective technique for combating inflammation. In this perspective, the series of titled compounds (10a-j) were designed, synthesized, and characterized following with the anti-inflammatory, analgesic, and ulcerogenic evaluation. The investigation of the potentiality of the titled compounds (10a-j) displayed a high degree of anti-inflammatory activity. The compounds displaying potential analgesic activity were identified and validated further for evaluation of analgesic, anti-inflammatory activity, and subsequent ulcerogenic evaluation. In addition, the COX-1, COX-2, and 5-LOX analyses were carried out in vitro. Among (10a-j) series, compound 10c with para substitution of fluoro group on the benzoyl ring and two chloro groups at ortho position in phenyl ring of benzophenone was observed to have good inhibitory potency. Furthermore, the in silico docking study was performed by using AutoDock tools docking software. (C) 2022 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Heterocycle; Analgesic; Anti-inflammatory; COX-1/COX-2 inhibition; 5-LOX inhibition; Ulcerogenic evaluation; Docking study |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Yuvaraj college > Chemistry |
| Depositing User: | C Swapna Library Assistant |
| Date Deposited: | 04 Sep 2023 06:02 |
| Last Modified: | 04 Sep 2023 06:02 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/17695 |
Actions (login required)
 |
View Item |
