T3P(R) facilitated one pot multicomponent reaction comprising unique intra-molecular rearrangement

Shamanth, S. and Sandhya, N. C. and Yatheesh, N. and Sunilkumar, M. P. and Mamatha, M. and Rangappa, K. S. and Kempegowda, M. (2022) T3P(R) facilitated one pot multicomponent reaction comprising unique intra-molecular rearrangement. Synthetic Communications, 52 (8). pp. 1122-1130. ISSN 1532-2432

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Official URL: https://doi.org/10.1080/00397911.2022.2072746

Abstract

Present work describes the T3P(R) mediated one pot four component reaction between 2-aminoacetamide, methylene-active carbonyl compounds, S-8 and isothiocyantes in synthesizing 1-(3-cyanothiophen-2-yl)-3-phenylureas. The strategy developed here comprises Gewald reaction followed by the T3P intervened unique intra-molecular rearrangement. The novel and eco-friendly route achieved here is operationally facile and offers versatile 1-(3-cyanothiophen-2-yl)-3-phenylureas, which are expected to show good biological activities.

Item Type: Article
Uncontrolled Keywords: Intra-molecular rearrangement; T3P; thiophene
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: C Swapna Library Assistant
Date Deposited: 01 Aug 2023 09:38
Last Modified: 01 Aug 2023 09:38
URI: http://eprints.uni-mysore.ac.in/id/eprint/17676

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