Preetham, H. D. and Umashankara, M. and Sharath Kumar, K. S. and Shobith, R. and Rangappa, K. S. (2022) Identification of β-aminopyrrolidine containing peptides as β-amyloid aggregation inhibitors for Alzheimer's disease. Journal of Peptide Science, 28 (6). e3386. ISSN 1099-1387
Full text not available from this repository. (Request a copy)Abstract
Alzheimer's disease (AD) is caused by a series of events initiated by the production and aggregation of the amyloid β-protein (Aβ). In the early stages of the disease, Aβ is released in a soluble form then progressively forms oligomeric, multimeric, and fibrillar aggregates, triggering neurodegeneration. Thus, development of inhibitors that initiate reverse Aβ aggregation is thought to be a logical approach in treating AD. In this context, we developed β-aminopyrrolidine containing 12 mer peptide 3 which is very potent in inhibiting the Aβ aggregation and also reducing Aβ(42)-induced cytotoxicity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Alzheimer's disease, amyloid β-protein, amyloid β aggregation, β-aminopyrrolidine |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | C Swapna Library Assistant |
| Date Deposited: | 15 Jun 2023 05:38 |
| Last Modified: | 15 Jun 2023 05:38 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/17529 |
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