Synthesis of some novel piperidine fused 5-thioxo-1H-1,2,4-triazoles as potential antimicrobial and antitubercular agents

Rishikesan, R. and Karuvalam, Ranjith P. and Muthipeedika, Nibin Joy and Sajith, Ayyiliath M. and Eeda, Koti Reddy and Pakkath, Rajeesh and Haridas, K. R. and Bhaskar, Vaishnav and Narasimhamurthy, K. H. and Muralidharan, A. (2021) Synthesis of some novel piperidine fused 5-thioxo-1H-1,2,4-triazoles as potential antimicrobial and antitubercular agents. Journal of Chemical Sciences, 133 (1). pp. 1-12. ISSN 0973-7103

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Abstract

A novel series of analogues based on 5-(1-(4-chloro-3-methoxyphenyl)piperidin-4-yl)-4-phenyl-2H-1,2,4-triazol e-3(4H)-thione core have been synthesized and their potential as antibacterial, antifungal and antitubercular agents was examined. The structure-activity relationship (SAR) studies of these derivatives 5 (a-k) clearly indicate the vital role of lipophilicity as a major factor in enhancing the biological activity of these compounds. Among the compounds screened, 5a, 5c, 5d, 5j and 5k displayed significant activity against Mycobacterium tuberculosis H37Rv strain.Graphic abstract

Item Type:	Article
Uncontrolled Keywords:	Piperidine; Triazole; Antibacterial activity; Antimycobacterial
Subjects:	C Chemical Science > Organic Chemistry
Divisions:	Department of > Organic Chemistry
Depositing User:	Mr Umendra uom
Date Deposited:	07 Mar 2022 05:27
Last Modified:	01 Jul 2022 10:27
URI:	http://eprints.uni-mysore.ac.in/id/eprint/17254

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