Kumaradhas, P. and Kalyanam, N. and Ravikumar, K. and Mohan, K. C. and Sridhar, M. A. and Shashidhara Prasad, J. and Nirmala, K. A. (1999) (+)-cis-3-hydroxy-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzo thiazepine 1-oxide. Acta Crystallographica Section C-Crystal Structure Communications, 55 (4). pp. 614-615.
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Abstract
The title compound, C16H15NO4S, is a diltiazem drug intermediate. Diltiazem is an enantiomerically pure drug with calcium antagonist activity. The molecular packing is stabilized by hydrogen bonding. The amide and hydroxide groups form hydrogen bonds with neighbouring molecules. The seven-membered ring is in a twist-boat conformation. The methoxyphenyl group deviates slightly from planarity but the benzene ring is planar.
| Item Type: | Article |
|---|---|
| Subjects: | D Physical Science > Physics |
| Divisions: | Department of > Physics |
| Depositing User: | Users 23 not found. |
| Date Deposited: | 17 Jun 2021 07:20 |
| Last Modified: | 07 Jul 2022 09:55 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/16805 |
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