Spectrophotometric assay of some antipsychotropic and anticholinergic phenothiazine drugs using ammonium molybdate

Basavaiah, K. and Krishnamurthy, G. (1998) Spectrophotometric assay of some antipsychotropic and anticholinergic phenothiazine drugs using ammonium molybdate. Analytical Letters, 31 (6). pp. 1037-1046. ISSN 0003-2719

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Abstract

A simple, rapid and sensitive spectrophotometric method has been described for the quantitative determination of six phenothiazine-based antipsychotropic and anticholinergic drugs in pure form as well as in formulations. The method is based on the formation of stable phenothiazonium free radical cation by the use of ammonium molybdate as chromogenic agent. The drugs in 3.0 to 5.0M H2SO4 medium when heated in a boiling water bath react with molybdate to give intense orange or purple or blue products which possess characteristic absorption maxima at 500-638 nn. Beer's law is obeyed over the concentration range 1-60 mu g.ml(-1) with apparent molar absorptivities ranging from 4.37x10(3)-9.61 x 10(3) L mol(-1). cm(-1). The proposed method has been applied successfully for the determination of examined drugs both in pure form and representative pharmaceutical formulations. The accuracy and precision of the assay method are comparable with those of the official method.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Users 23 not found.
Date Deposited:	05 Jun 2021 07:25
Last Modified:	05 Jun 2021 07:25
URI:	http://eprints.uni-mysore.ac.in/id/eprint/16734

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