Rudrammaji, L. M. S. and Veerabasappa Gowda, T. (1998) Isolation and characterization of an endogenous inhibitor of phospholipase A(2) from Indian cobra (Naja naja naja) venom. Toxicon, 36 (4). pp. 639-644.
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A PLA(2)-inhibitor has been purified from Indian cobra (Naja naja naja) venom by the combination of ion-exchange and gel-filtration chromatography. The inhibitor, NN-I-3 was a peptide with mol.wt 6500 and has a fluorescence emission maxima cn 340 nm. NN-I-3 specifically inhibited the enzyme activity of the three acidic PLA? from the same venom. The inhibition of NN-I-2d-PLA(2) and NN-I-2e-PLA(2) by NN-I-3 was of mixed type and NN-I-2c-PLA(2) was of uncompetitive type, Neither the inhibitor nor the individual mixtures of acidic PLA(2) with the inhibitor (1:1 w/w or 1:2 mol:mol) were lethal to mice when injected intraperitoneally in doses up to 10 mgkg(-l) body weight. (C) 1998 Elsevier Science Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Subjects: | C Chemical Science > Biochemistry |
| Divisions: | Department of > Biochemistry |
| Depositing User: | Users 23 not found. |
| Date Deposited: | 07 Jun 2021 03:48 |
| Last Modified: | 12 Jul 2022 06:48 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/16724 |
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