Babu, A. S. and Veerabasappa Gowda, T. (1995) Effects of chlorpromazine on the enzymatic and toxic properties of the most basic phospholipase A2 fromVipera russelli snake venom. Inflammation Research, 44 (8). pp. 340-344.
Full text not available from this repository. (Request a copy)Abstract
The effect of chlorpromazine on various biological activities of phospholipase A(2) VRV-PL-VIIIa from Vipera russelli snake venom was investigated. The drug inhibited the in vitro phospholipase A(2) activity of the enzyme by 55%. The ID50 was found to be 1.15 mu M. Increasing substrate concentration relieved the inhibition of phospholipase A(2) activity by the drug indicating probable interaction with the substrate. The drug totally quenched the fluorescence intensity of the enzyme. Chlorpromazine increased the LD(50) Of the enzyme by 1.6 fold. The drug also inhibited hemolytic and anticoagulant potencies but failed to inhibit edema inducing activity and myotoxicity of the enzyme.
| Item Type: | Article |
|---|---|
| Subjects: | C Chemical Science > Biochemistry |
| Divisions: | Department of > Biochemistry |
| Depositing User: | Users 23 not found. |
| Date Deposited: | 21 May 2021 05:17 |
| Last Modified: | 01 Jul 2022 11:39 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/16492 |
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