Multi-targeted quinazolinone-Schiff's bases as potent bio-therapeutics

Ullas, B. J. and Rakesh, K. P. and Shivakumar, J. and Chenne Gowda, D. and Chandrashekara, P. G. (2020) Multi-targeted quinazolinone-Schiff's bases as potent bio-therapeutics. Results in Chemistry, 2.

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Abstract

Two series of quinazolinone derived Schiff's bases were synthesized and characterized by analytical and spectro- scopic techniques. All the compounds were screened for their in vitro biological studies. The in vitro antioxidant activities of these compounds were evaluated employing 1,1-diphenyl-2-picryl-hydrazyl (DPPH), 2,2-azinobis- (3-ethylbenzothiazoline-6-sufonic acid) (ABTS + ) and N,N-dimethyl-p-phenylenediamine dihydrochloride (DMPD + ) radical assay. The results revealed that compounds 31 (IC 50 : 35 μg/mL) and 32 (IC 50 : 40 μg/mL) showed excellent antioxidant activity and their IC50 is lower than the IC50 of standards such as butylated hydroxyl anisole, ascorbic acid and gallic acid in all the three performed assays. In anti-inflammatory activity, compounds 7–26 (IC50: 10-35 μg/mL) showed extraordinary activity compared to standards indomethacin (IC50: 40 μg/mL) and ibuprofen (IC50: 65 μg/mL). In antimicrobial activity, compounds 25–42 shows potent antibacterial activity and compounds 25–42 shows potent antifungal activity compared to standards streptomycin (ZoI: 10 mm) and bavistin (ZoI:10 mm) respectively. To study the structure activity relationship (SAR), electron donating groups (-OH and -OCH 3 ) favors the antioxidant activity, electron withdrawing groups (\\F, \\Cl, \\Br and -NO2) favors the anti-inflammatory activity, and both electron donating (-OH and -OCH3) and electron with- drawing (\\F,\\Cl,\\Br and -NO2) groups (25–32) or heterocyclic moiety (33–42) favors antimicrobial activity. © 2020 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http

Item Type:	Article
Additional Information:	cited By 3
Subjects:	C Chemical Science > Chemistry
Divisions:	Yuvaraj college > Chemistry
Depositing User:	Mr Umendra uom
Date Deposited:	22 Apr 2021 06:46
Last Modified:	30 Jun 2022 05:28
URI:	http://eprints.uni-mysore.ac.in/id/eprint/16085

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