Swetha, Hari and Swaroop, T. R. and Preetham, H. D. and Mohan, C. D. and Umashakara, M. and Basappa, S. and Vlodavsky, Israel and Sethi, Gautam and Rangappa, K. S. (2020) Synthesis, Cytotoxic and Heparanase Inhibition Studies of 5-oxo-1-arylpyrrolidine-3-carboxamides of Hydrazides and 4-amino-5-ary1-4H-1,2,4-triazole-3-thiol. Current Organic Synthesis, 17 (3). pp. 243-250. ISSN 1875-6271
Full text not available from this repository. (Request a copy)Abstract
Design of chemically novel, biologically potent small heterocyclic molecules with anticancer activities, which targets the enzyme heparanase has gained prominent clinical interest. We have synthesized a novel class of carboxamide derivatives by coupling various substituted aromatic acid hydrazides and triazoleamine with pyrrolidine carboxylic acid by using coupling agents. The synthesized compounds are characterized by spectroscopic techniques such as FT-IR, DIMS and NMR. These compounds arc investigated for cytotoxicity on different cancer cell lines and heparanase inhibitory activity. Most of them showed moderate heparanase inhibitory activity and good cytotoxicity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Hydrazides triazole; carboxamides; cytotoxicity; heparanase; pyrrolidine |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Mr Umendra uom |
| Date Deposited: | 03 Feb 2021 06:19 |
| Last Modified: | 28 Jun 2022 07:37 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/15660 |
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