Anil, S. M. and Sudhanva, M. S. and Swaroop, T. R. and Vinayaka, A. C. and Rajeev, N. and Kiran, K. R. and Shobith, R. and Sadashiva, M. P. (2020) Base Induced Condensation of Malononitrile with Erlenmeyer Azlactones: An Unexpected Synthesis of Multi-Substituted Delta(2)-Pyrrolines and Their Cytotoxicity. Chemistry & Biodiversity, 17 (5). ISSN 1612-1880
Full text not available from this repository. (Request a copy)Abstract
An efficient, metal free approach to synthesize multi-substituted Delta(2)-pyrroline derivatives by mild base catalyzed cyclocondensation of malononitrile with Erlenmeyer azlactones via 1,2 addition was developed. The modularity of this reaction was used to assemble a range of poly-substituted pyrrolines. Further, synthesized products were screened for cytotoxic properties on different cancer cell lines such as A549 (Human lung adenocarcinoma cells), HeLa (Human cervical adenocarcinoma cells), Jurkat (Human chronic myeloid leukemia cells) and K562 (Human leukemic T cell Lymphoblast cells). Among the synthesized library of compounds, 6f and 6q displayed potent cytotoxic activity.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Erlenmeyer azlactones; pyrrolines; condensation reaction; 1; 2-addition reaction; cytotoxicity |
| Subjects: | C Chemical Science > Organic Chemistry |
| Divisions: | Department of > Organic Chemistry |
| Depositing User: | Mr Umendra uom |
| Date Deposited: | 17 Feb 2021 05:57 |
| Last Modified: | 18 Jul 2022 07:28 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/15590 |
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