Kumar, K. M. Prabhu and Kumar, B. C. Vasantha and Kumar, P. Raghavendra and Butcher, Ray J. and Vivek, H. K. and Suchetan, P. A. and Revanasiddappa, H. D. and Foro, Sabine (2020) Synthesis, characterization, CT-DNA binding and docking studies of novel selenated ligands and their palladium complexes. Applied Organometallic Chemistry, 34 (6). ISSN 1099-0739
Full text not available from this repository. (Request a copy)Abstract
A novel selenated Schiff base (S)-(LH)-H-1 has been synthesized from (2S)-1-(benzylselanyl)-3-phenylpropan-2-amine which upon reduction formed a reduced Schiff base (S)-(LH)-H-2. Palladium (II) complexes (S)-1 and (S)-2 of ligands (S)-(LH)-H-1 and (S)-(LH)-H-2 respectively were successfully synthesized. The structures of all four compounds were thoroughly identified by analytical and various spectroscopic techniques. The absolute molecular structures of the above two complexes were further confirmed by single crystal X-ray diffraction. Both (S)-(LH)-H-1 and (S)-(LH)-H-2 coordinated as monobasic ((S)-L1-2), chelating, tridentate (Se,N,O-) ligands resulting in the complexes of composition (S)-PdCl(L-1/2)] (S)-1/2]. In the crystals of complexes (S)-1 and (S)-2, there were moderate to strong SeMIDLINE HORIZONTAL ELLIPSISO, CHMIDLINE HORIZONTAL ELLIPSISCl and CHMIDLINE HORIZONTAL ELLIPSISO types of intermolecular secondary interactions. CT-DNA binding activity of these selenium-containing ligands and their palladium complexes bearing a Pd-Se bond have been evaluated for the first time by performing electronic absorption titration and fluorescence emission quenching using CT-DNA-EB and viscometric experiments. These ligands and complexes exhibited remarkable DNA binding activity as shown by their intrinsic DNA binding constants (K-b) and Stern-Volmer constants (K-sv) in the ranges 5.2-9.9 x 10(4) and 3.6-4.7 x 10(4), respectively. The viscosity of CT-DNA decreases with increasing concentration of these compounds. The results of the DNA-binding studies revealed that all of the compounds interact with DNA at a minor groove which was further confirmed by molecular docking studies.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DNA binding; molecular docking; palladium complex; secondary interactions; selenium |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Mr Umendra uom |
| Date Deposited: | 19 Feb 2021 05:26 |
| Last Modified: | 19 Feb 2021 05:26 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/15579 |
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