A novel and facile synthesis of 3,5-Disubstituted isothiozoles under metal free conditions using acetophenones and dithioesters

Nagaraju, Chaithra and Ashok, Swarup Hassan and Shamanth, Sadashivamurthy and Nagarakere, Sandhya C. and Sunilkumar, Makanahalli P. and Subbegowda, Rangappa Kanchugarakoppal and Mantelingu, Kempegowda (2020) A novel and facile synthesis of 3,5-Disubstituted isothiozoles under metal free conditions using acetophenones and dithioesters. Synthetic Communications, 50 (17). pp. 2647-2654. ISSN 1532-2432

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Abstract

A facile and conveniently simple new protocol is devised for the synthesis of 3,5-disubstituted and annulated isothiozoles under transition metal and catalyst free conditions utilizing easily available acetophenones, dithioesters and NH4OAc. This strategy involves C=O and C=S functionalization via sequential imine formation followed by intra molecular cyclization and aerial oxidation forming consecutive C-N and S-N bonds respectively in one pot. This protocol offers a low cost, user friendly, straight forward and widely applicable approach to 3,5-disubstituted isothiazoles.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	Mr Umendra uom
Date Deposited:	24 Feb 2021 06:25
Last Modified:	24 Feb 2021 06:25
URI:	http://eprints.uni-mysore.ac.in/id/eprint/15543

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