Lokesh, K. S. and Chaya, S. K. and Jayaraj, B. S. and Praveena, A. S. and Krishna, Murali and Madhivanan, Purnima and Mahesh, P. A. (2020) Vitamin D deficiency is associated with chronic obstructive pulmonary disease and exacerbation of COPD. Clinical Respiratory Journal. ISSN 1752-699X
Full text not available from this repository. (Request a copy)Abstract
Introduction Low Vitamin D levels have been associated with Chronic Obstructive Pulmonary Disease (COPD) and acute exacerbations. Objectives There is a paucity of data on Vitamin D and COPD, its severity and exacerbations in populations that are exposed to sunlight regularly with high levels of physical activity most of their lives. Methods Serum levels of 25-OH-Vitamin-D were assessed in 100 COPD subjects and 100 age- and gender-matched controls from the rural community-based MUDHRA cohort in South India. Levels of <20 ng/mL were defined as Vitamin D deficiency. Smoking habits, occupation, Charlson co-morbidity index, Standard of living index(SLI), body mass index(BMI), 6-minute walking distance were examined for associations with logistic regression between controls and COPD subjects. Unconditional logistic regression was used to examine the association with exacerbation of COPD. Results Vitamin D deficiency was observed in 64.5% (95%CI 57.7-70.8) of the subjects in spite of regular exposure to sunlight. Subjects with COPD had higher risk of Vitamin D deficiency (Adjusted OR: 5.05; 95%CI 1.4-17.8) as compared to controls. Amongst subjects with COPD, Vitamin D deficient subjects were three times more likely to have exacerbations in the previous year (Adjusted OR:3.51; 95%CI 1.27-9.67) as compared to COPD subjects without Vitamin D deficiency. Levels of Vitamin D <20.81 ng/mL and <18.45 ng/mL had the highest levels of combined sensitivity and specificity for COPD and acute exacerbation of COPD (AECOPD) respectively. Conclusion In a rural population exposed to sunlight many hours a day throughout their lives, low Vitamin D levels were associated with COPD and exacerbations of COPD.
| Item Type: | Article |
|---|---|
| Subjects: | E Mathematical Science > Statistics |
| Divisions: | Department of > Statistics |
| Depositing User: | Mr Umendra uom |
| Date Deposited: | 03 Apr 2021 05:21 |
| Last Modified: | 01 Jun 2022 07:17 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/15459 |
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