Puttaswamy, N. and Rekha, N. D. and Lakshmi Ranganatha, V. and Prashanth, T. and Khanum, S. A. (2018) Anti-inflammatory and antioxidant activity of salicylic acid conjugated dihydropyrazoline analogues. Journal of Applied Pharmaceutical Science, 8 (2). 060-064.
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Abstract
Syntheses of substituted salicylic acid appended pyrazoline analogues (7a-j) via 1,3-dipolar cycloaddition were reported earlier. In the present investigation we have performed the anti-inflammatory activity by phospholipase A2 (PLA2) inhibition and in vitro antioxidant activity by 2,2-diphenyl-1-picrylhydrazyl, nitric oxide, hydroxyl radical scavenging assay and ferrous ion chelating assay wherein compounds 7d, 7h, 7i and 7j have shown maximum anti-inflammatory activity. Further, compounds 7d, 7f and 7h were proved to be excellent free radical scavengers.
| Item Type: | Article |
|---|---|
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Yuvaraj college > Chemistry |
| Depositing User: | Manjula P Library Assistant |
| Date Deposited: | 15 Jan 2021 10:24 |
| Last Modified: | 15 Jan 2021 10:24 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/15433 |
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