Thimmaiah, K. N. and Thomas, M. J. and Sethi, V. S. and Made Gowda, N. M. (1990) Desorption chemical ionization and field desorption mass-spectrometric analysis of antitumor catharanthus (VINCA) alkaloids. Microchemical Journal, 41 (2). pp. 183-190.
Full text not available from this repository. (Request a copy)Abstract
Antitumor Catharanthus (Vinca) alkaloids, vinblastine and vincristine, and their chemically modified derivatives N-deformylvincristine, N-deformyl-4-deacetylvincristine, vindesine, 4-deacetylvinblastine, and 4-deacetylvincristine, after purification by high-pressure liquid chromatography were analyzed using the soft ionization technique of desorption chemical ionization mass spectrometry or field desorption mass spectrometry. The dominant signal from the free bases by these techniques was their respective protonated molecular ion. These studies suggest that these techniques can be conveniently applied for characterization of the metabolites and/or in vitro degradation products of the antitumor alkaloids.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | Chemistry, Analytical |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Dr Raju C |
| Date Deposited: | 21 Jan 2021 09:49 |
| Last Modified: | 11 Jul 2022 11:47 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/15377 |
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