Solution-phase synthesis of novel Δ2-isoxazoline libraries via 1,3-dipolar cycloaddition and their antifungal properties

Basappa and Sadashiva, M. P. and Mantelingu, K. and Swamy, S. Nanjunda and Rangappa, K. S. (2003) Solution-phase synthesis of novel Δ2-isoxazoline libraries via 1,3-dipolar cycloaddition and their antifungal properties. Bioorganic & Medicinal Chemistry, 11 (21). 4539 - 4544.

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Abstract

The synthesis of novel imidazolyl substituted δ2-isoxazoline libraries are currently of high interest. We report here in the full details of a study leading to the synthesis and antifungal activities of 3-(-2-butyl-4-chloro-1H-imidazolyl)-substituted δ2-isoxazolines. The solution phase synthesis of the title compounds was accomplished via 1,3-dipolar cycloaddition of in situ generated nitryl oxides from aldoximes with mono substituted alkenes to obtain the compound libraries contain an imidazole functionality in addition to the isoxazoline rings. The newly synthesized compounds when tested in vitro in solid agar culture exerted a potent antifungal activity against Aspergillus flavus, Fusarium moniliforme and Botrydiplodia theobromae also MIC values were determined. The title 5-substituted-3-imidazolyl-δ2-isoxazoline compounds represent a novel class of potent antifungal agents.

Item Type:	Article
Subjects:	C Chemical Science > Chemistry
Divisions:	Department of > Chemistry
Depositing User:	LA manjunath user
Date Deposited:	22 Dec 2020 06:43
Last Modified:	22 Dec 2020 06:43
URI:	http://eprints.uni-mysore.ac.in/id/eprint/14270

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