Jayanthi, G. P. and Veerabasappa Gowda, T. (1988) Geographical variation in India in the composition and lethal potency of russell's viper (Vipera russelli) venom. Toxicon, 26. p. 257.
Full text not available from this repository. (Request a copy)Abstract
Venom samples of Russell's viper from 3 localities in India were analyzed for their composition and toxicity. Column chromatog. fractionation on CM-Sephadex C-25 showed the absence of 3 fractions in the venom samples of southern India compared with the samples from northern and western India. The SDS-PAGE pattern of southern Indian venom samples also showed lack of 3 protein bands corresponding to mol. weights of 66,000, 39,000 and 9000. Venom samples from northern and western India possessed high acidic phospholipase activity while acidic phospholipase activity was absent in the samples from southern India, which in contrast showed large basic fractions with phospholipase activity. Proteolytic activity was present in all the venom samples; however, this activity, as well as trypsin inhibitor activity, was very low in the southern Indian samples. The ratio of proteolytic activity to inhibitor activity remained constant in most of the venom samples studied. LD50 values for most of the venom samples from northern and western India were twice as high as that of the samples from southern India. High phospholipase activity correlated with high lethal potency in the venom samples studied.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | India, Russell viper venom geog variation, Vipera venom geog variation, nonhuman, Mice, Animal, viper venom, Lethal Dose 50, Non-U.S. Gov't, snake, snake venom, Support, Viper Venoms, lethality, Comparative Study, Electrophoresis, ld 50, Polyacrylamide Gel, Esterases, phospholipase, Phospholipases, reptile, Peptide Hydrolases, geographic distribution, Geography, india, Sodium Dodecyl Sulfate, Trypsin |
| Subjects: | C Chemical Science > Biochemistry |
| Divisions: | Department of > Biochemistry |
| Depositing User: | Dhruva Kumar |
| Date Deposited: | 05 May 2021 12:00 |
| Last Modified: | 12 Jul 2022 06:05 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/13158 |
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