Channe gowda, D. and Rajesh, B. and Shankare gowda (2000) Ammonium formate catalytic transfer hydrogenation: a convenient method for removal of halogenated benzyloxycarbonyl and benzyl protecting groups in peptide synthesis. Indian J. Chem., Sect. B: Org. Chem. Incl. Med. Chem., 39B. pp. 504-508.
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Abstract
A new application of ammonium formate catalytic transfer hydrogenolysis, in the presence of palladized carbon, for removal of 2-chlorobenzyloxycarbonyl (2-ClZ), 2,6-dichlorobenzyl (2,6-Cl2Bzl), bromobenzyloxycarbonyl (BrZ) and phenacyl ester (OPa) from amino acids, peptides and high mol. weight polymers is reported. For example, Boc-Tyr(2,6-Cl2Bzl)-Gly-Gly-Phe-Leu-OC4H9-t was deblocked in \textless 15 min. with a yield of �92%. For longer peptides, ammonium formate deblocking gave a yield of �87%, vs. 52% for HF treatment.
| Item Type: | Article |
|---|---|
| Additional Information: | Publisher: National Institute of Science Communication, CSIR |
| Uncontrolled Keywords: | ammonium formate hydrogenolysis preparation peptide deblocking protective group |
| Subjects: | C Chemical Science > Chemistry |
| Divisions: | Department of > Chemistry |
| Depositing User: | Dhruva Kumar |
| Date Deposited: | 28 Apr 2021 13:49 |
| Last Modified: | 28 Apr 2021 13:49 |
| URI: | http://eprints.uni-mysore.ac.in/id/eprint/12818 |
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