Effects of Carbon Tetrachloride on Mitosis

Seshachar, B. R. and Parvathi K. Nambiar (1955) Effects of Carbon Tetrachloride on Mitosis. Nature, 176 (4486). p. 796.

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Abstract

WE have observed that carbon tetrachloride produces striking effects on Allium cepa, Allium sativum and Zaphranthus sp. root tips. Root tips were treated for five minutes to a half-hour in carbon tetrachloride and later transferred to normal nutrient medium and fixed at various intervals from half an hour to six hours. Among the prominent changes taking place in the resting nucleus is a dissolution of the nuclear membrane and an outflow of its contents. Similar observations have been made in root tips of Allium cepa treated with chloroform1 and potassium cyanide2. It would appear that the lipoid layer of the nuclear membrane is either dissolved or rendered weak by the chemicals, in consequence of which the nuclear contents flow out. After treatment for 15 min. with carbon tetrachloride, resting and premitotic nuclei break up. A number of chemicals are known to produce this effect, for example, urethane3 and nitrogen mustard4. Perhaps the most characteristic changes brought about by carbon tetrachloride are dissolution of chromatin in the resting nucleus and disorganization of the chromosome arms in the premitotic stages, resulting in their progressively negative reaction to the Feulgen reagent.

Item Type:	Article
Additional Information:	Place: Hampshire Publisher: Nature Publishing Group
Uncontrolled Keywords:	mitosis, Mitosis, cell division, Cell Division, carbon tetrachloride, Carbon Tetrachloride, drug effects
Subjects:	B Life Science > Zoology
Divisions:	Department of > Zoology
Depositing User:	Dhruva Kumar
Date Deposited:	17 May 2021 10:05
Last Modified:	17 May 2021 10:05
URI:	http://eprints.uni-mysore.ac.in/id/eprint/12165

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