Antihyperglycemic and hypolipidemic effect of Morus Indica L. in streptozotocin induced diabetic rats

Vishalakshi Devi, D. and Asna Urooj (2014) Antihyperglycemic and hypolipidemic effect of Morus Indica L. in streptozotocin induced diabetic rats. Annals of Phytomedicine, 3 (2). pp. 55-59. ISSN 2393-9885

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The present study evaluated the long term hypoglycemic effect of Morus indica L. in rats induced with diabetes, to determine the changes in activity of glycolytic and gluconeogenic enzymes and to compare the effect of Morus indica L. with conventional antidiabetic drugs - Insulin and Glibenclamide (OHA). Morus indica L. was obtained from the Department of Studies in Sericulture, University of Mysore, India. The antihyperglycemic effect of the plant was tested in streptozotocin induced diabetic rats. The effect of Morus indica L. on carbohydrate metabolizing enzymes was also studied. Morus indica powder (MIP) at a level of 500mg/kg body weight, reduced blood glucose level in the animals by 42 after 45 days. The blood glucose in animals supplemented with MIP decreased from an initial level of 257± 69.4 to 148.8 ± 34.48 mg/dl. The activity of aldolase in the liver of MIP and Insulin treated groups was 0.19u/g and in Glibenclamide treated group, it was 0.18u/g protein. The activity of G-6-PDH decreased significantly (p<0.05) in untreated diabetic group (0.24 ± 0.04 mIU/mg). The G-6-PDH levels in MIP, Insulin and Glibenclamide treated group were 1.38 ± 0.48, 0.98 ± 0.10 and 1.04 ± 0.42 mIU/mg protein, respectively which were higher compared to the diabetic control group. The activities of AsAT and AlAT decreased significantly in animals treated with Morus, Insulin and Glibenclimide. The results prove that Morus could effectively reduce the blood glucose, total cholesterol, triglycerides and also reverse the activity of elevated enzymes which can prove beneficial in the management of hyperglycemia.

Item Type: Article
Uncontrolled Keywords: Morus Indica L. and Mulberry and Aldolase and Antihyperglycemic and Glucose-6-Phosphate Dehydrogenase and Hypolipidemic
Subjects: B Life Science > Food Science and Nutrition
Divisions: Department of > Food Science and Nutrition
Depositing User: Users 19 not found.
Date Deposited: 30 Sep 2019 05:29
Last Modified: 30 Sep 2019 05:29

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