Crystal and molecular structure studies of cinnarizinium dimaleate

Chidan Kumar, C. S. and Naveen, S. and Venkatachalapathy, R. and Anilraj, K. N. and Chandraju, S. (2013) Crystal and molecular structure studies of cinnarizinium dimaleate. Der Pharma Chemica, 5 (1). pp. 51-54.

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The title salt systematic name: 1-diphenylmethyl-4-(2E)-3-phenylprop-2-en-1-ylpiperazine-1,4-diium bis (hydrogen maleate), crystallizes in the monoclinic space group P21, with a = 9.940 (2) à , b = 27.115 (6) à , c = 11.802 (3) à , β = 98.403 (3)°, V = 3146.8 (12) à and Z = 2. The piperazine ring is protonated at both the N atoms and adopts a distorted chair conformation. The sum of the bond angles around the piperazine N atoms N1 and N2 indicates that they are sp3 hybridized. The structure exhibits both intra- and intermolecular hydrogen bonds of the type O-H O and N-H O.

Item Type: Article
Uncontrolled Keywords: article, unclassified drug, drug structure, hybridization, crystallization, X ray crystallography, hydrogen bond, piperazine derivative, crystal structure, drug conformation, nitrogen, maleic acid, hydrogen, 1 diphenylmethyl 4 (3 phenylprop 2 en 1 yl)piperazine 1, 4 diium bis(hydrogen maleate), chemical bond, cinnarizine, proton transport
Subjects: D Physical Science > Sugar Technology
Divisions: PG Centre Mandya > Sugar Technology
Depositing User: Arshiya Kousar
Date Deposited: 13 Sep 2019 05:28
Last Modified: 13 Sep 2019 05:28

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