Synthesis of new series of 5,6-dihydro-4H-1,2-oxazines via hetero diels-alder reaction and evaluation of antimicrobial activity

Manjula, M. K. and Rai, K. M. L. and Gaonkar, S. L. and Raveesha, K. A. and Satish, S. (2009) Synthesis of new series of 5,6-dihydro-4H-1,2-oxazines via hetero diels-alder reaction and evaluation of antimicrobial activity. European Journal Of Medicinal Chemistry, 44 (1). pp. 280-288. ISSN 1768-3254

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Official URL: http://doi.org/10.1016/j.ejmech.2008.02.027

Abstract

A new series of 5,6-dihydro-4H-1,2-oxazines were synthesized via hetero Diels-Alder reaction of alpha-nitrosoolefins with alkenes. alpha-Nitrosoolefins were generated from ketoximes by the action of chloramine-T. The newly synthesized compounds were characterized with IR, NMR, elemental analysis and screened for their antimicrobial activity; they exhibited excellent antimicrobial activity. The minimal inhibitory concentration of the compounds was in the range of 10-35 mu g ml(-1) for bacteria and 10-40 mu g ml(-1) for fungi. (C) 2008 Elsevier Masson SAS. All rights reserved.

Item Type: Article
Uncontrolled Keywords: Synthesis; 1,2-Oxazines; Antimicrobial activity; Chloramine-T
Subjects: B Life Science > Botany
B Life Science > Microbiology
C Chemical Science > Chemistry
Divisions: Department of > Botany
Department of > Chemistry
Department of > Microbiology
Depositing User: Shrirekha N
Date Deposited: 29 Aug 2019 10:06
Last Modified: 29 Aug 2019 10:06
URI: http://eprints.uni-mysore.ac.in/id/eprint/7325

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