Synthesis and microbial inhibition study of novel 5-imidazolyl substituted isoxazolidines

Sadashiva, M. P. and Mallesha, H and Hitesh, N. A. and Rangappa, K. S. (2004) Synthesis and microbial inhibition study of novel 5-imidazolyl substituted isoxazolidines. Bioorganic and Medicinal Chemistry, 12 (24). pp. 6389-6395. ISSN 0968-0896

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Official URL: doi:10.1016/j.bmc.2004.09.031


Cycloaddition of C-imidazolyl-N-phenylnitrotles with monosubstituted alkenes afforded 5-imidazolyl substituted isoxazolidines with high regioselectivity. Novel isoxazolidines were screened for their antibacterial activities against S. aureus, E. coli and B. subtilis by using streptomycin as a positive control. They were also tested for their antifungal activities against E moniliforme, A. niger and C. acremonium by using nystatin as a positive control. Isoxazolidines, 4a and 4f exhibited more potent inhibition towards antifungal activity than the other isoxazolidines prepared. (C) 2004 Elsevier Ltd. All rights reserved.

Item Type: Article
Uncontrolled Keywords: antimicrobial properties; synthesis; nitrones; isoxazolidine derivatives; cycloaddition
Subjects: C Chemical Science > Chemistry
Divisions: Department of > Chemistry
Depositing User: Users 23 not found.
Date Deposited: 05 Sep 2019 07:22
Last Modified: 05 Sep 2019 07:22

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