Synthesis of coumarin-theophylline hybrids as a new class of anti-tubercular and anti-microbial agents

Sumitra Mangasuli, N. and Kallappa Hosamani, M. and Devarajegowda, H. C. and Kurjogi, Mahantesh M. and Joshi, Shrinivas D. (2018) Synthesis of coumarin-theophylline hybrids as a new class of anti-tubercular and anti-microbial agents. European Journal of Medicinal Chemistry, 146. 747 - 756. ISSN 1768-3254

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Official URL: https://doi.org/10.1016/j.ejmech.2018.01.025

Abstract

A series of novel coumarin-theophylline hybrids were synthesized and examined for their anti-tubercular activity in vitro against Mycobacterium tuberculosis H37Rv, anti-microbial activity in vitro against gram-positive bacteria (Staphylococcus aureus) and gram-negative bacterias (Escherichia coli, Salmonella typhi) as well as fungi (Candida albicans). The compound (3a) has shown excellent anti-tubercular activity with MIC of 0.12 μg/mL. Electron donating compounds (3a, 3f) have displayed significant anti-microbial activity. The compounds have also been precisely elucidated using single crystal X-ray diffraction techniques. Molecular docking study has been performed against 4DQU enzyme of Mycobacterium tuberculosis showed good binding interactions and is in agreement with the in vitro results.

Item Type: Article
Uncontrolled Keywords: Coumarin-theophylline hybrids, Molecular docking, Anti-tuberculosis, Anti-microbial, X-ray structure
Subjects: D Physical Science > Physics
Divisions: Yuvaraj college > Physics
Depositing User: Manjula P Library Assistant
Date Deposited: 11 Jul 2019 11:18
Last Modified: 11 Jul 2019 11:18
URI: http://eprints.uni-mysore.ac.in/id/eprint/5092

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